In recent years, as the mortality from cancer is increasing in the world, the development of anticancer drugs is considered as one of the most important research. Epthilones appear as new anticancer agents that can inhibit tumor, therefore many people in the world are interested in it. Epthilones are mainly obtained through the process of biosynthesis by the strain Sorangium cellulosum- one kind of myxobacteria. In the production and manufacturing process of Epothilones, Amberlite XAD-16 that can effectively adsorb Epothilones is widely used, previous results of investigations show that it plays a very important role in the adsorption of Epothilones produced in the fermentation. However, because of high cost and a large amount consumption of XAD-16, the porous adsorption resin XD-5 replaces Amberlite XAD-16 in China. The porous adsorption resins such as Amberlite XAD-16 and polyamide resin are being used in the adsorption, separation and purification of various natural products such as flavonoids. In this paper we mentioned the data on the the adsorption and desorption effect of porous Nylon-6-resin with Epothilone B, compared to the effect of Amberlite XAD-16 and porous adsorption resin XD-5 resin. The result showed that the adsorption and desorption rate of Nylon-6-resin were similar to that of Amberlite XAD-16 and porous adsorption resin XD-5 in Epothilone B standard solution. And the effect of the sort and concentration of elution agent, elution time and extract number were examined in the desorption of Nylon-6-resin with Epothilone B. In conclusion, Nylon-6-resin can be used effectively for the purification of Epothilone B in the future.
| Published in | Journal of Drug Design and Medicinal Chemistry (Volume 9, Issue 3) |
| DOI | 10.11648/j.jddmc.20230903.12 |
| Page(s) | 35-38 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Epothilone B, Nylon-6-Resin, Adsorption, Desorption, Amberlite XAD-16, XD-5 Resin
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APA Style
Ho, M., Ri, I., Cho, G., Kim, G., Ri, H. (2023). The Adsorption and Desorption Effects of Nylon-6-resin with Epothilone B. Journal of Drug Design and Medicinal Chemistry, 9(3), 35-38. https://doi.org/10.11648/j.jddmc.20230903.12
ACS Style
Ho, M.; Ri, I.; Cho, G.; Kim, G.; Ri, H. The Adsorption and Desorption Effects of Nylon-6-resin with Epothilone B. J. Drug Des. Med. Chem. 2023, 9(3), 35-38. doi: 10.11648/j.jddmc.20230903.12
AMA Style
Ho M, Ri I, Cho G, Kim G, Ri H. The Adsorption and Desorption Effects of Nylon-6-resin with Epothilone B. J Drug Des Med Chem. 2023;9(3):35-38. doi: 10.11648/j.jddmc.20230903.12
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Download@article{10.11648/j.jddmc.20230903.12,
author = {Myongchol Ho and Inchol Ri and Gyonghak Cho and Gwangsu Kim and Hyegyong Ri},
title = {The Adsorption and Desorption Effects of Nylon-6-resin with Epothilone B},
journal = {Journal of Drug Design and Medicinal Chemistry},
volume = {9},
number = {3},
pages = {35-38},
doi = {10.11648/j.jddmc.20230903.12},
url = {https://doi.org/10.11648/j.jddmc.20230903.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20230903.12},
abstract = {In recent years, as the mortality from cancer is increasing in the world, the development of anticancer drugs is considered as one of the most important research. Epthilones appear as new anticancer agents that can inhibit tumor, therefore many people in the world are interested in it. Epthilones are mainly obtained through the process of biosynthesis by the strain Sorangium cellulosum- one kind of myxobacteria. In the production and manufacturing process of Epothilones, Amberlite XAD-16 that can effectively adsorb Epothilones is widely used, previous results of investigations show that it plays a very important role in the adsorption of Epothilones produced in the fermentation. However, because of high cost and a large amount consumption of XAD-16, the porous adsorption resin XD-5 replaces Amberlite XAD-16 in China. The porous adsorption resins such as Amberlite XAD-16 and polyamide resin are being used in the adsorption, separation and purification of various natural products such as flavonoids. In this paper we mentioned the data on the the adsorption and desorption effect of porous Nylon-6-resin with Epothilone B, compared to the effect of Amberlite XAD-16 and porous adsorption resin XD-5 resin. The result showed that the adsorption and desorption rate of Nylon-6-resin were similar to that of Amberlite XAD-16 and porous adsorption resin XD-5 in Epothilone B standard solution. And the effect of the sort and concentration of elution agent, elution time and extract number were examined in the desorption of Nylon-6-resin with Epothilone B. In conclusion, Nylon-6-resin can be used effectively for the purification of Epothilone B in the future.
},
year = {2023}
}
TY - JOUR T1 - The Adsorption and Desorption Effects of Nylon-6-resin with Epothilone B AU - Myongchol Ho AU - Inchol Ri AU - Gyonghak Cho AU - Gwangsu Kim AU - Hyegyong Ri Y1 - 2023/12/28 PY - 2023 N1 - https://doi.org/10.11648/j.jddmc.20230903.12 DO - 10.11648/j.jddmc.20230903.12 T2 - Journal of Drug Design and Medicinal Chemistry JF - Journal of Drug Design and Medicinal Chemistry JO - Journal of Drug Design and Medicinal Chemistry SP - 35 EP - 38 PB - Science Publishing Group SN - 2472-3576 UR - https://doi.org/10.11648/j.jddmc.20230903.12 AB - In recent years, as the mortality from cancer is increasing in the world, the development of anticancer drugs is considered as one of the most important research. Epthilones appear as new anticancer agents that can inhibit tumor, therefore many people in the world are interested in it. Epthilones are mainly obtained through the process of biosynthesis by the strain Sorangium cellulosum- one kind of myxobacteria. In the production and manufacturing process of Epothilones, Amberlite XAD-16 that can effectively adsorb Epothilones is widely used, previous results of investigations show that it plays a very important role in the adsorption of Epothilones produced in the fermentation. However, because of high cost and a large amount consumption of XAD-16, the porous adsorption resin XD-5 replaces Amberlite XAD-16 in China. The porous adsorption resins such as Amberlite XAD-16 and polyamide resin are being used in the adsorption, separation and purification of various natural products such as flavonoids. In this paper we mentioned the data on the the adsorption and desorption effect of porous Nylon-6-resin with Epothilone B, compared to the effect of Amberlite XAD-16 and porous adsorption resin XD-5 resin. The result showed that the adsorption and desorption rate of Nylon-6-resin were similar to that of Amberlite XAD-16 and porous adsorption resin XD-5 in Epothilone B standard solution. And the effect of the sort and concentration of elution agent, elution time and extract number were examined in the desorption of Nylon-6-resin with Epothilone B. In conclusion, Nylon-6-resin can be used effectively for the purification of Epothilone B in the future. VL - 9 IS - 3 ER -
Institute of Microbiology, The State Academy of Sciences, Pyongyang, DPR Korea
