Journal of Drug Design and Medicinal Chemistry

Volume 3, Issue 2, April 2017

  • LC-MS, GC-MS, and NMR Spectroscopy Based Evaluation of the Energy of Consciousness Healing Treated Withania somnifera (Ashwagandha) Root Extract

    Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Ariadne Esmene Afaganis, Barbara Marie Bader, Brian A. Weekes, Daphne Luisa Dumas, Denise Marie Fiedler, Dennille Mellesia Smith, Desi Pano, Donna Felice Galla, Donna Maria Alija, Elaine Barbara Mullins, Elaine M. Scorza, Ellia O'Donnell, Fabio Massimo Paciucci, Frances Goodman Warlick, Haddon Norman Salt, Inthirani Arul, Jacqueline Y. Andrews, James Jay McLeran, James Stephen Burnett, Jean Caroline White, Parthasarathi Panda, Kalyan Kumar Sethi, Snehasis Jana

    Issue: Volume 3, Issue 2, April 2017
    Pages: 18-26
    Received: 14 March 2017
    Accepted: 27 March 2017
    Published: 18 April 2017
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    Abstract: Withania somnifera root extract which contains withanolides as major active constituent and it is used traditionally for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect® - Consciousness Energy Healing Treatment on the structural properties of the ashwagandha ro... Show More
  • Design, Synthesis and Cytotoxicity Evaluation of Structural Analogues of Imatinib

    Aliaksandr Faryna, Elena Kalinichenko, Olga Avdoshko, Alla Belko

    Issue: Volume 3, Issue 2, April 2017
    Pages: 27-31
    Received: 28 February 2017
    Accepted: 21 April 2017
    Published: 19 May 2017
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    Abstract: Several novel imatinib structure analogues were synthesized. Antiproliferative activity testing on various leukemic cell lines showed 1-2 fold less activity against K562 cells compared to imatinib. Autodock Vina’s docking studies predicted no differences in binding affinity of the titled compounds while positive relationship between activity and ca... Show More